Bio-Nanomaterials

toc1Nanomedicine “the application of nanotechnology to health” has been growing exponentially in the last two decades. In this regard, multifunctional nano-scaled materials have been developed for applications in fields such as drug delivery, diagnostics, biosensing and bioengineering. Our group is mainly interested in developing innovative functional nano-scaled systems that can be used both for diagnostic and therapeutic purposes.[1,2] Particularly, given our expertise in Fluorine Chemistry, one of our main objectives is developing innovative fluorinated nanomaterials for application as contrast agents in 19F-MRI.[3,4] We are also interested in the fundamental understanding of the interaction between nanomaterials and biological matter in the perspective to improve the design of such systems. Moreover, another area of intense research in our group is the study of how selective halogenation of biomolecules (e.g., proteins, peptides, etc.) can change their structure, self-assembly behavior, and function and be then involved or contribute in/to the mechanism and progression of many diseases (e.g., Alzheimer's, Parkinson's, etc.).[5]

References:
1. D. Maiolo, P. Del Pino, P. Metrangolo, W. J. Parak, F. Baldelli Bombelli, Nanomedicine delivery: does protein corona route to the target or off road? Nanomedicine 2015, 10, 3231.
2. D. Di Silvio, N. Rigby, B. Bajka, A. Mayes, A. Mackieb, F. Baldelli Bombelli, Technical tip: high-resolution isolation of nanoparticle–protein corona complexes from physiological fluids. Nanoscale 2015, 7, 11980.
3. V. Dichiarante, I. Tirotta, L. Catalano, G. Terraneo, G. Raffaini, M. R. Chierotti, R. Gobetto, F. Baldelli Bombelli, P. Metrangolo, Superfluorinated and NIR-luminescent gold Nanoclusters. Chem. Commun. 2017, 53, 621.
4. L. Gazzera, R. Milani, L. Pirrie, M. Schmutz, C. Blanck, G. Resnati, P. Metrangolo, M. P. Krafft, Design of highly stable echogenic microbubbles through controlled assembly of their hydrophobin shell. Angew. Chem. Int. Ed. 2016, 55, 10263.
5. A. Bertolani, L. Pirrie, L. Stefan, N. Houbenov, J. S. Haataja, L. Catalano, G. Terraneo, G. Giancane, L. Valli, R. Milani, O. Ikkala, G. Resnati, P. Metrangolo, Supramolecular amplification of amyloid self-assembly by iodination. Nature Commun. 2015, 6:7574, DOI: 10.1038/ncomms8574.

 

 


 

 

 

 

 

 

 

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